Synopsis
This is the seventh one day event organised by SCI’s Young Chemists’ Panel to highlight the challenges associated with ADMET (Absorption, Distribution, Metabolism, Elimination and Toxicity) in medicinal chemistry. The aim of the day is to provide participants with a practical understanding of ADMET parameters, how to diagnose common ADMET problems and how to improve compound design to overcome these problems. Topics will include how to identify problems with solubility, permeability, clearance, duration and chemical-related toxicology; how to interpret data from commonly used non-efficacy tests; and real life examples of solutions to ADMET problems.
Attendees
The event is aimed at organic chemists (graduate or PhD) working within a pharmaceutical research environment and students thinking about a career in this sector. Participants are provided with a booklet containing the material presented, worked examples and literature references.
SCI Members attending this meeting are able to claim CPD points.
Programme
09.15 Registration and refreshments
09.55 Introduction and welcome
10.00 Absorption
• Practical understanding of concepts & parameters
• How do you know you have a problem?
• Sources of problem – Solubility, Permeability, PGP Efflux
• Chemical strategies to improve absorption
• Worked examples
11.15 Refreshment break
11.45 Metabolism and clearance I
• Practical understanding of concepts & parameters
• How do you know you have a problem?
• Sources of problem - Phase I / Phase II Metabolism
• Chemical strategies to address metabolism
• Worked examples
13.00 Lunch
14.15 Metabolism and clearance II
• Cytochrome P450s and Drug-Drug interactions
• Volume of distribution – how to understand and influence
• Plasma protein binding – impact & influence
• Worked examples
15.45 Refreshment break
16.15 Drug toxicity and toxicology
• Context & common issues
• Design strategies to mitigate risks of hERG, phospholipidosis, reactive
metabolites & genotoxicity
17.15 Summary and closing remarks
17.30 Wine reception
Speakers
Dr Darren McKerrecher, AstraZeneca
Dr Ted Parton, Mekinopsis Ltd
Dr Peter Astles, Eli Lilly
Organising Committee
Dr Liz Jones, SCI/UCB
Dr Gail Wrigley, SCI/AstraZeneca
Dr Nina Ursinyova, SCI/Evotec
Exhibition
An exhibition will take place alongside the conference during refreshment breaks for companies and related organisations who may wish to exhibit. For further information and prices, please email conferences@soci.org. Spaces are limited and will be allocated on a first come, first served basis.Delegate Fees
Early bird fees before Monday 24 April 2017
One day fee
GB£115 . . . . . . . . . . . . . . . . SCI Member
GB£40 . . . . . . . . . . . . . . . . . SCI Student Member
GB£170 . . . . . . . . . . . . . . . ..Non-Member
Two days fee
GB£200 . . . . . . . . . . . . . . . . SCI Member
GB£70 . . . . . . . . . . . . . . . . . SCI Student Member
GB£300 . . . . . . . . . . . . . . . ..Non-Member
SCI Platinum Corporate Members receive 25% off the above rates
Standard fees after Monday 24 April 2017
One day fee
GB£140 . . . . . . . . . . . . . . . . . SCI Member
GB£50 . . . . . . . . . . . . . . . . . . SCI Student Member
GB£205 . . . . . . . . . . . . . . . . . Non-Member
Two days fee
GB£240 . . . . . . . . . . . . . . . . . SCI Member
GB£85 . . . . . . . . . . . . . . . . . . SCI Student Member
GB£360 . . . . . . . . . . . . . . . . . Non-Member
SCI Platinum Corporate Members receive 25% off the above rates
This is the seventh one day event organised by SCI’s Young Chemists’ Panel to highlight the challenges associated with ADMET (Absorption, Distribution, Metabolism, Elimination and Toxicity) in medicinal chemistry. The aim of the day is to provide participants with a practical understanding of ADMET parameters, how to diagnose common ADMET problems and how to improve compound design to overcome these problems. Topics will include how to identify problems with solubility, permeability, clearance, duration and chemical-related toxicology; how to interpret data from commonly used non-efficacy tests; and real life examples of solutions to ADMET problems.
Attendees
The event is aimed at organic chemists (graduate or PhD) working within a pharmaceutical research environment and students thinking about a career in this sector. Participants are provided with a booklet containing the material presented, worked examples and literature references.
SCI Members attending this meeting are able to claim CPD points.
Programme
09.15 Registration and refreshments
09.55 Introduction and welcome
10.00 Absorption
• Practical understanding of concepts & parameters
• How do you know you have a problem?
• Sources of problem – Solubility, Permeability, PGP Efflux
• Chemical strategies to improve absorption
• Worked examples
11.15 Refreshment break
11.45 Metabolism and clearance I
• Practical understanding of concepts & parameters
• How do you know you have a problem?
• Sources of problem - Phase I / Phase II Metabolism
• Chemical strategies to address metabolism
• Worked examples
13.00 Lunch
14.15 Metabolism and clearance II
• Cytochrome P450s and Drug-Drug interactions
• Volume of distribution – how to understand and influence
• Plasma protein binding – impact & influence
• Worked examples
15.45 Refreshment break
16.15 Drug toxicity and toxicology
• Context & common issues
• Design strategies to mitigate risks of hERG, phospholipidosis, reactive
metabolites & genotoxicity
17.15 Summary and closing remarks
17.30 Wine reception
Speakers
Dr Darren McKerrecher, AstraZeneca
Dr Ted Parton, Mekinopsis Ltd
Dr Peter Astles, Eli Lilly
Organising Committee
Dr Liz Jones, SCI/UCB
Dr Gail Wrigley, SCI/AstraZeneca
Dr Nina Ursinyova, SCI/Evotec
Exhibition
An exhibition will take place alongside the conference during refreshment breaks for companies and related organisations who may wish to exhibit. For further information and prices, please email conferences@soci.org. Spaces are limited and will be allocated on a first come, first served basis.Delegate Fees
Early bird fees before Monday 24 April 2017
One day fee
GB£115 . . . . . . . . . . . . . . . . SCI Member
GB£40 . . . . . . . . . . . . . . . . . SCI Student Member
GB£170 . . . . . . . . . . . . . . . ..Non-Member
Two days fee
GB£200 . . . . . . . . . . . . . . . . SCI Member
GB£70 . . . . . . . . . . . . . . . . . SCI Student Member
GB£300 . . . . . . . . . . . . . . . ..Non-Member
SCI Platinum Corporate Members receive 25% off the above rates
Standard fees after Monday 24 April 2017
One day fee
GB£140 . . . . . . . . . . . . . . . . . SCI Member
GB£50 . . . . . . . . . . . . . . . . . . SCI Student Member
GB£205 . . . . . . . . . . . . . . . . . Non-Member
Two days fee
GB£240 . . . . . . . . . . . . . . . . . SCI Member
GB£85 . . . . . . . . . . . . . . . . . . SCI Student Member
GB£360 . . . . . . . . . . . . . . . . . Non-Member
SCI Platinum Corporate Members receive 25% off the above rates
