ࡱ> a R=,bjbjzzF0P\P\ Id4d4AAAAAAAA83B$WBDAfBB(BBB DEd}E4Ͷ϶϶϶϶϶϶$V-AH D DHHAABBH  M M MHABABC2 MHͶ M M6g3iBд9Ikh/60fhHJV83i3i(42$A[jE5F^ MFLFEEEKEEEfHHHHVEEEEEEEEEd4I @: Front. Chem. Sci. Eng. DOI 10.1007/s11705-017-****-* RESEARCH ARTICLE Title of the paper Firstname Lastname1, Firstname Lastname2, Firstname Lastname(*)3 1 Full Affiliation, Address 2 Full Affiliation, Address 3 Full Affiliation, Address Higher Education Press and Springer-Verlag GmbH Germany 2017 Received MM DD, 2017; accepted MM DD, 2017 E-mail: corresponding_author@email Abstract This is the abstract section. One paragraph only (Maximum 200 words). Keywords keyword, keyword, keyword (3-10 keywords separated by commas) 1 Introduction In-text citations must agree with the references in either numbering or names and year. The references should be presented completely and without mistakes, and should be the original publication. It should be listed in numerical order in the order in which they are cited in the text. Give the complete information, including names of all authors, titles of the article and periodicals or books, publication years, volumes, number, start and end pages. Journal tile should be in complete but not in abbreviation. Main text paragraph 2 Materials and methods Main text paragraph [add an equation here; use MS Word or MathType equation function](1) Main text paragraph 2.1 This is subsection heading Main text paragraph Table 1 Add a descriptive label of the table here Sample2/days4/days6/daysBlank control 61.571.468.0PLAa) 73.275.665.2HA-PLAb) 54.478.662.4a) PLA:; b) HA-PLA: *. Main text paragraph 2.1.1 This is subsection heading Main text paragraph [add the figure here, note: 1) unit of the variable in Figures should be presented by / but not in the bracket; 2)scale of the coordinate should be set inward]  Fig. 1 (a) Add a descriptive label of the figure here; (b) Add a descriptive label of the figure here; (c) Add a descriptive label of the figure here Main text paragraph 3 Results and discussion Main text paragraph Main text paragraph 4 Conclusions Main text paragraph Main text paragraph Acknowledgements The Acknowledgment section is the general term for the list of sponsor and financial support, contributions, credits, and other information included at the end of the text of a manuscript but before the references. Conflicts of interest and financial disclosures must be listed in this section. Authors should obtain written permission to include the names of individuals in the Acknowledgment section. Electronic Supplementary Material (if needed) Supplementary material is available in the online version of this article at http://dx.doi.org/[DOI] and is accessible for authorized users. Appendix (if needed) Appendix A A1, A2, A3 Appendix B References 1. Lchelt U, Wagner E. Invading target cells: Multifunctional polymer conjugates as therapeutic nucleic acid carriers. Frontiers of Chemical Science and Engineering, 2011, 5(3): 275286 2. Hofbauer J, Sigmund K. The Theory of Evolution and Dynamical Systems. London: Cambridge University Press, 1988, 2527 3. Chen B. Theoretical studies of dielectronic recombination for Be-like titanium, molybdenum, gold and lead ions and spectrum for highly ionized titanium and gold atoms. Dissertation for the Doctoral Degree. Chengdu: Sichuan University, 1998, 99100 4. Plank C J, Posinski E J. US Patent, 4081190, 1978-02-15     .Z   * , . 0 2   ( + , 6 7 A W X ` m n z | # # 9 e ÿvrhYKh&Wh&WKHaJnHtHh&Wh&WKHh&Wh&WaJ h&Wh&Wh h,L]h h&W5hhnHo(tHhhhUhmhR hm/h"CZ hm/hK0 hm/h&W h&WH*h&WOJPJQJ h"CZH*h"CZhB=hw9h&W,.j4 l - X |  # $ 9 Q e u$Ifgd_qgd_r`gd r$WD`a$gdngd_kgd_jgd_mgd_ggd_fgd_bgd_2gd_ )07>E~uiii |$$Ifa$gd` |$Ifgd_zgd_qgd_ogd_r`gdDFg\kd$$If 0$'$U'622 F44  aytP0 u$$Ifa$gd_ )/067=>DEFTUYZ^_cdehjklpquvz{| %v|Ph:jzh6_UaJhkCho(CJaJhkChkCCJaJhkCh&WCJaJhYKhUh&WH* hth&Wh&Wh&WaJ h&Wh&W h&W5 hI{5h&Wh#wkA&QQ*bV20170821172247RftZ2H.-FftZ2H.JFIF``C    $.' ",#(7),01444'9=82<.342C  2!!22222222222222222222222222222222222222222222222222" ߀3p1  ?I)20b kJ" _sPE2:孏^q|"q^v"ؖ˜_"p]l"Ź}zF_Z{ ě[_-+''P7Alϣa2 ڮ5>V:Ee>VgC5i9#PX15/[SVC_ >} g \7ٙM_aOliTwiӐ /YmB<)ϮTϗ.tM5 d_Q<u 2,l5Hie|.=d9yks:L*tYv1ݭWkQs/2:/=Z}"m4Il22Z,˜l ))OD2so"n#[Bxgثg&\egnwJZJˮY/xmʠs\]ڡI /崶ue94N0}ߓ i?%:/Gy_iH)7gף| ψf{ǟMg }F_Pe9m.2h3_a|hTfm_Q?lzN2]`En@ /]VwKh%P˪'7rf`ؒ=Y48m\./q/=`ktgP5h 9޿?oe !?I 򇾇A2@a@ ֗-ϰ4=m&o`}F_P뫯kWX )˻ׄx2ugѤe}@MƷԳX5{QctsgL^XDe;^h/g:~WӬl;.@1mCe'.[Ro9a:ZV%G._Qvj*[qy^ՖuR2x@ Whs $Ȓ[S,,>Tzk 70ɚ2 <[S˷X5fWz1d:TI|X=169mH?Iy2]L/ԍx|!TiM:g7a2V3\e5TGaFo)w>}F_P7Ϫ. ;xuK1"$cB *mbcǺǺB7 \˙=e}@ {eU=\K4ҦsȘ<-Q= j e9ToֈD344ғi_ΫN[s> Q}S}U->Hr*Ke W"Eze}@Ez H)ˀQ1{Y>9*֤5^E"`+`+`+`+`1zK^^^^_Os,zWzWzWzW}WzWzWzWzWX X X X X "Kfm>"/ORGsZAknUS[E!ص*w9|nI]YyVpxyP~3{| o@e(\&`#u./$'PCqǧ`q$ ra˜4zvϔjttx}K6oѢe5If,Vz1R4 zg$ji4>ڷɱ?P305P"@`!#$ 1463%&2p¯v+RO 8Fdk؏m3Q,T${Xݞ /_>g-<]']x{<<"ۑy773q373s+7Rsv#7yw7wЅכóV~jE^56 Yٸɛcm`\a?wnr5*fwxƁ3Dvصܶn693%uŭqj`ͥS4ǝs!Ukq`ᝏo-82g^8#Qa")ڧ&ů ueVHmtn!`dt$a,I#bc9?fU$ѰYGÎJW#ۓ?iLVhHt׭y"I~M/|X $7\K?p ;eW2wgn?T.>#t;=:5/H%۳IGٟ6ƍ/_9"gsRD,<=~ݟW/\b~էW/x"j*Y$OE۵^'1r|`ԩ{ 'Ab3ǖf,~VlH>)Qyk nSf<21W7Tl0eGNaKoo$X+jIF `@2icyavr$Cv_q\v6ȕl?Nu'hthJjbT1>o;*W;V'sQY ٚduJUAD~?[/4~G 0_,"YCjh60'L c{w/GN}ZܿQGeUwn3+?d5G^O_bч=fD:Ǻ&ڳ,2,|>VP^Wtn w;>Gg {dfk,qܘv/Tjd/t7XEg|C`'+gHaRS9fFJɣ(5f?~͓+)Xk,#tNEuq֗f~_x26zHoIwun·3/$xʇG$T*@İ] eNY9ՆoӰWo\v-!İۿ~vN/u %еlHlwpY9glN.v\'`"ىcB ۿ~Q$/ˆ5d kOrZW0>?<:ֻ%跡Í82;!ƽ#"ɑ0ٲ[)Þ%duɯ,s}#$٦<|iE"~qXcA=%o)QDV+GZ` (Fܛ/_/|Xd3#aYp[|{W* @FĊ?79{ZcqFluO:صJXEb7b3F_Y!!&uk\rqj.(\3ja\Z cTӿbE,Y/G_{ ud8ׇ"zKn?X Z@ R0v__UM5}6?_^meƆ䪍I/DbDD1 b)K/כX^$XԬ!WKMM:8R.TiT+}?-T§sA ig<&_%[n YXC: 8:9"ycp+ ?/_g8;?o_;^V;_o_~-uD?/4L^Ah4Kȿ_dءu`RNҞM͙=L51-ij7qsUuvqOgʼnŮqj͢͝3i\L53`bqnsZ5'k Lș73yL[3x7x7xsw7xsw7x3w6"]/.9:1F2_n@P1푘9XBVWC;Rc~,Kz},"2k'ju!=kz]F*9f/^_~ou_~ou_~ou_~ou_~ouZu_~ou_~ou_~ou_~ou奠dW n au_~ou_~ou_~ou_~ou,K7{7{7{7{7.(@{7{7{7{7{Í݇\?ȺQ;VF6FCy4!<ЇBhCy4!<ЇBhCy4!<ЇBhCy4!<ЇBhCy4!<ЇBhCy4!<ЇBhCy4!<ЇBhCy4!<ЇBhCy4!<ЇBhCy4!<ЇBhCy4!<ЇBhCy4!<ЇBhC4n- J8Ĕ-UQj=P !-Kt^I*<67iܞxD*a䊾5Ș۫&􋵗a ܚI>qxT=x(qh{TѤ9Q w/[IKbWS ki[1 9r1E݊V5 ec;9R1e9X&sZorH3"H_LX"wy%dA E6G"gvQ-6J؇:?LИ|l+ʌ IG4$N0q{_"Te(:QQkD6f9w*[C$dMZZYc)V%FJ[O)";F9ȬBc9ː4( sKsh 7(^w4"G 8؀.?p뫼 nw,5Ϟx:RGI)>I'>ܟ-40Q !12PA"a0R#BCq34@p?AUUU6l>U XC_>7TuKb\ v[%Ssm*nf g Ÿ`RS,'Nn!~ŚxIAKʤNh g?*T>=p_mAKS&jfKEss/jM}7fw1Cۚ'٦Fj X{wCnj2eo$t l4QX{veguNm&YӚ[[&;min;!78x(>;$l')0QD8%bH"6X)*r-#QĸUC.VcR%7oG+y YJF}B;\{~Gxg} ښf'PG1T,O#nmAOXmeVX*AR_uK}1.Q.?L  !"14Q02APaqr#3@B`Rbs 5SCp$ct?=,/;#muBY*okۭ=kNCEncs@|R͕,y5+E\|ԃ7axn@bԎ90EjN՝C#Û`oV, ͅX^ "B=Ȕzs+^cBMw Xʱzx#yhKO(Y.ؚ@8ء MBE~'ffw[ W UW-,XW}=!_X]>qGFKԯ3dʯ¾~ڥ^žj^PMnn΃c 2>`4pQCA$prcЯ=,]۰VI@܆a^r|.?*OwC#ݣ؊=L̨tleY$*4Kejy =4Zs&pԿJ*wW9>žlޜ۬$\,>Şg=8fcwسS^5 E*2FͯVVi5Äny594{eZ о&<8>˅30fwց>Za dazczCf'(tQT墪K/VȌN8:y=X.lp=h5Hq90ܞxwX ?p I0 U{t=!D)w'/;1Ged:WN(wSFpI8'`&ؠ-7lmaFmܥoHv lm{M%C][8F#Mfq]k W!0E'VE~> _LHRJ}FOhdl;9us SEhvLRF-){>&c.dE増 |Y_|5{ hߵΥj5v1i@ɰzCa:oEQmwѸ6Ffr,pİemԇ8ׅTVB鰨##3ҴܲԦ-֡[&ʵ:Ѷ(=>pڭ&ѽj=Ji/Žԩ<.iGXW="WAz ?5 +$sk]9U%X Nssۡ/*Lͅ^NY2eGT[,Wpa0A_~Sh!/2Þ sa8#Z8Jex$lgkpBX]y5.{nr0bI9?V+ՊG1F7oNu)vͶ[=0mmVKk?ðzC w*{c{7|Nh~j) Nwe} þJ*\`?27Hg<\j)cm+ȅI9Y2i}YbEwaHqR11->t zC0uyH\՞ηa#zq3šyY2Y3%Բ%eYYQ[  ?Bş%f=k9[/=XOXN:u[^huyֱy?ZGyo +zVb¸Qk31es,zoayWjMUccߕh|Pm3r ďWEM֐\}X$yGM릗 ;4ϾFDPVD݋1$΢{ J x}YFv0E3p"kZDϺk,Q:Z/Ve}RB8gTGY'O]~3{A0l= w;ZGq H;ix-#wഎw;ZGq H;ix-#wഎw;V-#znVw;ZGq H;ix-#wഎw;ZGq H;ix-#wഎw;RמiAtP1͍KH;ix-#wഎw;ZGq H;ix-#wഎw;ZGq H;ix)-o0ݽtix-#wഎw;ZGq H;ix-#wഎw;ZGq H;ix-#;=\'R9&EҴw;ZGq H;ix-#wഎw;ZGq H;ix-#wഎw;hqXmT>LUh?ppQSD3JdBW Y%O߰Z4X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0X;0g!t1J0?Onܥ! ^<*I,҈K*+]$*9~+3:Sd1G&\@ϻ.Wb UPj6qRsE\@wx^ձVG&%Zy [L7DÈU22Cz#ْwB? )HF_bKhP`DePƜjX iGVDd5']&8թQbKāg_G[H-w"wQSxQQ֣+ԫ fAKƍEU7u! 1ƤSP st 3j4Qv]\l;O i ~Q>J+L, crV1 )8mQG׵6WoKV@$j)%3!̢weu( Ɛi{8R3^Ej0ݕf>hsIḞHI*O? VE O2| UY*>NYgaPF!YZN{? Z %wQe<ի޾NAV;8`sv%t֚ԟ~A}wYd Rgsķ|y_Qɶ5ⱾJ= Z+؟YIZPz'8)vصV# Mz ;*7o+J37YvJO(ϻ6 6|ͺ}PQɄsqmrL: ی[RB4VgGʠ 9l]JmLn@xSr\4pn6]+;:cʀ$o3?kė8N^ZNen=/u|G3ZKA,OA۶;ڛwAbcΧP-&`YVPjݭjo? t޴T9e+]J{e6J52|ݠ\&:G<4p z2F450I׏*1\WA4fu,<_tFS5x3<^&f9cӜXcNl 6Ft𫱰4r+09Di9νVûƆ*lכ`F4Ll .uڷI/멢tEg86vCg@j#u5$XQe/`sd"s@;0gqWh^~aCg=({3ݲNf73iɑԽUp[~ oB˗oy\-3,ݱ^ ɽ[}K}NյⱽU V> -е&S?I?,󕦠U)Q-#ӟ%=TkAپ<0V!*C+%gV` S ]u6-32~;35myq4XT_pe9í1Q3+ʠI+F2P^ Z'D1&B:++Z}rݰks4/٤ڧmF6~<.>pF-Omos)"Vn [Q=W,rFG5* ͡ى4Ԭ3b *< F!8Ad>C$5{ u_֙\1qvEMd¸$({Cu+.S,!1AQaq0P@` p?!4HX7x쑢:AJϱ=p?3#4њ3P"$nhmlZwr`,q~ϫ:<'AqTvN.EÛ$URE?v ax/6w&_[i/O_3uf8}TG\]4> ,ڪ_1J+N eNqSĔё.lFRlZ+J*oL(Y6e N053_>L'Z?֌6։Y2lP_z֌-2 #dh,\T$J>A &CL倀&h HS*TLH9Hp3QR K҉FX*joxTAS,i@cP6D>0:մ8>$:Ҙ < ,c\i<|i(R!)d3(g6[8x `m\ |%p 13 )c Rdl΅2 AmӇJ׹FD Oq'ErQHq}@ /c^l\2T\YB:x?1OGDr5,]ؘQt!G,/gN(Iyqʑ'#]tZx%Rz3vV$ ([ dV!o89$ҋ>Bn e9L ӴYѮɧ,8@1h Sp7W♽1c7W+]VtRNDh~5 ,.($MN 4$ "=G@PvM( xL}Bbp@0r.d0OuO /sE(m)6Kُ{[/Z[hZvY7>v v(VePY l1pcK-`V c8-#@H\eaC'ɇNϪ2yNvFfA$53x"K6V`9eu;\m7I6~Qri{Ʀ,897V{+M`t ćϖ$5+gsDVBSГ(PnO,XI'&E[zn"}4[„N8 ֓L&朮AjT'Ƣ# }DmQn CN=d`ioĴ@j,sOLl[{Б=HX[Pr鶏ZNg[T.n”$I>w&+H=ZܰՏ֘n&čX31w{;ʛ/ݙ#<`ݹ/BAqr<Zw)5:#-C~[rTǢ>8RrWJntVFZdh˕,SHb J\%:kgNjr)xYi&ZlW@4Gխ b^ sx/}leIRʵ)qn[Ҡ FrUu bcvUYu?@Jϱ=D v&~)uûKBҚLPr*HA.GOXO'~44:T8 ɉ1+>Ќ>%[pt:rYG%:sh^2p>cl%qb!글urMF%is̽IaOyBU7S1Y.݋ `u^RMS c'U:l1=5.HJzHb ; ʤb[E`ŏX۠I*oƥw,<6LTZXZΥ9+)*iA({O9 %ww GeJ4g'xmb㏢3mQpf.^6DeJnO#A  [ PV߄';EJ5q'֛~7@dʀڊ24#P0X1e)W&x.} QTҾswkMQ`w^z΢ܓX%\)g>syc'BS-ďW:])ތBR"Ϻͻ U#0VJ1/!{Rz8[<%yƱ3_vzVqFR=CBF^F&Y\@OO[<;a[PpiG\pVLn+.QlgiKd1b'mHg'ƆYz43=`JH_b^t,{C'jtkt %e<%VZfLsFN;@g6oQ7>}  +1= .A/8yfq”ґIb.Ėax sze>ԥ6z e^D`w8xee`ղ= Z$'IiN_6=vD;[W( @߶4 v[Q|t>}٠HMSfc5cY[)6~x,hdݏܨL8=ĨP{+{a|sX۟Ϗ~T>`oWZ]}?V$O='n8PyVPV>И?lJ^-}wvt-$x_CW-CoNYΚ]^4*L9QF4_Q̏ƻ΄ PT4iJ%҄C1x¡Z$C.C4觗8L,A٠XKI9 ;JC ijYB{f~1+wR0hA"jIf(&3ċy .&MPF3ֲ Cڈɽs* BJaH eD    Y.h    !`Fxh'/AAAAA, AAAA!TeVĜr? AAAA0jYdÉ̾&XJNMq{$S8{wZ-pc}T 6h0_bFld&ƕ!gnIgUd>h'&/׆Xͭ؅] bmKtr[ưKf8aS*{O J+Ʉ߇C!0f5)CX\%P{{&hWsFuTh?@4Ǵ<<<<<<<<<<<<<^O<<<<<<<<<<<-<<<<<<< <<<<<<<>;<<<<<<<<<<<<<x\P;u!6eV:g:Rvu# */܃FS>/:%A³ǯ:糧UVƻ⎭ḿ@ɴܾ!«S1@$]lh\u\\k*ߑ G |4iy DZQ?"9ޘDevbW]SX)-kՖ?cU}k(o:/|_W?J?O,1!APQa q0@p? $_xxʹNL U37sWU1VCiFrZ`Ԭ<1L}K6 h7H?j&'56eFUN,bV(wQgP+l5!XG+Sh`ԑyq` \7hcU aQԎ0nVW1wǿҘٯg ձVg:?do{=~H0Ȥ'UMpTw1YpۛV_,J tC[DJqv?bzwH" 5-1H;nr@j414.8¦a /O`m|>B¤3閑0'ϺͰ˷W|0ٚr|O-aj2*4<rGw e~A`{+P}Po ULz);:j=X)^W/wZY"eezm>w?~vKRqxhQ޽w!)|./ϳHuP9WZ%b锦yG}2%ӹ˪;a ǣ1N~tE#D}`{7]XC9NW6)DUzfYAKtB={ +(YUr;!;\'us܃, /$8F¯Saoe?5Ks)b>9 U]kSH.pu 0"&|/L@<%Mw^>"63=>C="Vs֪YQoՉșầ4*߳Ǚ0>7<炲7]3].qZlRаlir\ 0 z={PD9b8<'ˤu/EqhYۭdZzUW-t*s?iS~Ο~1 ӚՏ#l9jnKԶ>"ZъBܴJ+1O5 -m{6jhʸ .Xa]xE(&PfҢUJNzw RuR<FT(4W9^ƅZs@t } Uqfu~k_7 45Z]Nß Oy߀ 4R) yAƎOY jQbU]_D$Q_y߀8p݇C 6%qNlչ AFҳS%1?Oy߀;VpwDKm<WX0 Se lH)a85p3{s{-fy75KC՛a bGD;z,ԸQ&}r@LԊgӡYe~2ti9 W(4cVJi5x0n8%\hL\0D4}w~"P/|l/tT[ bt5Q-"(={-t&RLqP_E-)*[B*D^dD΍tQ}>-{'?8±Ib6 *#~׻ p>Zd;= P*#,/NZ'G& ֵ܂ GB<6.nb=7N>6NМ{Iu^yjHڕA˫D(/vth>F~vTMcН6I"L~;74{K}WٓV9p5A]p4`t)S,2o"=ֻ}G`lSaGEQk4Ryx`^ۀaKhPz>zw??S'(";b1B=~_6 Yx5l0\̻NXz4I\&􈣯WC.vKFDbʹFyF1h @`\iˁۋ(w (V^tPeH p_?rg9F}pC 1 ]TG H@v8\xl^׻47"/2d}ƒ݈iډ0<  u zwKqHln J_/]`_ "EwpI'W8a84#`/ O&& yT"DPu9YK ;=1TF={`~Rd8MLǮZ i2FRP5,GfobRhػPwI}^!1qH4G  QWg992}1T6x̒*xxȵt̋9%]m}w~vJIq-/d`D8`" Է.lJV W+kҩ 1M ‘P{}={ªEJN2u]ri%SN~1utDtHl8 gO`%F5# M#9=w~Gus;gb-U>Y|O в }>!þR.ӧ-ƒ7ؒ^?n<|~q0G99|Y\Uat #șߞ)MAۖ͞ "qǂںB6`ڐ䢔0ryY<%It%A|Ua0&fyEg?L03L`9@h-;}_,SI~@>ۡᱫղ6Bҳ*I<)<=u*YFzs6> hħ;Ch={3@7&-&Qά93N?g~hGmpt}fK "X{7ryn>H" :yXVRX+`B|\g]/^<H:MYW!"Xц:nɟs~©+VNTN(<"W_$Ajѹ:qEn> 8e {ڗ.lБsmf"Gy.#c#Ggāl8r%1ajݏ1+3|3ӎWF8XxXF #X]m )4/jmm ?dtQpb DM&mYE3`@zwE=RT?BaC|H#8X,B_@X_ <.Hʔzw.(«)vf#>9°踑&< uAjn9GPZZ #h>ea={^W]T7MкUtnnnҶ80={s^Fp^WP @%fDpNJ#튟W>Oww~NzPxW럏:zFB%{9ױP .C"纕y r#ڂP. KQ5S߈(`te}3~o:8+"ʽ^ U$}sHﯙakoFPJoH`U;p;߈> i׻}`/w~";pHؾG p[xBFr~p o'n߉K <]d~eW"L\l_wɢd`s 翦kr)O<蟚|R l>O??187whLCɞx,`w&_3?8'ssOG{'U짚.(HDT|BUt V!K1 N0-{n™z eDޚa96= jciԒ hN^VNɥ' GVA+ ы52;v]s;!ΚÐ0peVk>kwN|x~G݁HO =?$ȏuQ u-cNC}aqPKpLq^^qqqqQDBO~qqqq<~$lCB͹@xIb<~qqqq$ [_qqqqq9BxY*俆WUGqqqq?VB] \& >a:^0:mpE=+ސQh6\BI {^"@UfĔ_33,UI|\~*0=~akͦ5#&"]N/Uƅ] ZI82V+"h7L3,\$;./NT(]`}k=x!gWhYc5 Zzyd(oHGY@@fzwS'4v3CWO}f] p$D1h|1 Z\4"-LD$זzw¦U뾋vUm,d@u]!%&2<ށ1PU (=m늒T{=6 Ҍ^ %QtQ_$© L4k)CW|H] ̵L>; CcW& ziru) mFm\mK]4.RzR8/_6h44HO6@M m~ V͢ jx "鱴 P38)*`:B~$E`Xr4#SK(.КU(qz;9^ uh< NfU.*ډR{$_L٤yA8v >:c%Ðw~ npÅD ԎCz 4U + N>Ot"qc)vGCT{(]Xy>Kg E+וՐ[Fm Z{ۜ|\Sl]{,o5^0(#^EB+"BŖj H'I디9G ܖq_%BK@NsN"!Z J"긦VX+o <ÍʒX7v~(HcGcwW4TT`Co{iGוf0RŃ bjT!M7]l&A\)A{*^6 tQbaZ6,, NWAL-jezJ]zRg T Dg޷,CyQ(+1|"JvfGNhK,NNٮ)BeX9J{N\Œyf'p-$!XWwO+#ĄJ l jk߲>>?x.@xxǔ=:}ԭ^id7d(A.Ǖ|]eӾVkG"aWUֻ>_ f}_ O/枠Jen{6$dC?Н19 &0>%b\nEf~Xべ" 'D8QqM[ȚhHiK@$]JMqPcjT 79^IHW7rVa)8`2pkL8jl FňUM֙ѶK,du"!B$FmYMޙ[v7H, b^TM:Fa%MժIhjx])$M/+8sX@ >,˜;1'$PհR:n< fhYw\FHWԁ;AlK@y^ԁ;AlK@y^s666666666vvvvvvvvv66666>6666666666666666666666666666666666666666666666666hH6666666666666666666666666666666666666666666666666666666666666666662&6FVfv2(&6FVfv&6FVfv&6FVfv&6FVfv&6FVfv&6FVfv8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@PJ_HmH nHsH tH8`8 &WckeCJ_HaJmH sH tH b"b /yeh 2dd1$@&[$\$a$&5CJ$KHOJQJ\aJ$mHsHtH$A $ &W؞k=W[SOBi@B 0nfhr> 20yblFhe,gCJKHaJmHsHtH4/4 20 yblFhe,g CharCJaJ(' ( 20ybl_(uCJaJ(( 20ybleW[a$** 20 ybleW[ CharBjB 20ybl;N5CJKH\aJmHsHtH0/0 20 ybl;N Char5\"" 2trans*U * 20c >*B*ph@ @20O CJKH_HaJmH nHsH tHBB 2apple-converted-space, !, 20`SMO&{e,g B*phX^2X 20nf(Qz)#dd1$[$\$a$CJKHOJPJQJ^JaJ"A" 2titleLRL &2le,g%dG$a$CJKHPJaJmHsHtHB/aB %2 le,g CharCJOJPJQJ^JaJL rL 2e '$1$a$ CJKH_HaJmH nHsH tH2!2 20 Nf>f:_6B*]ph 2Emr^~1G:V)044j;@ j; jDjD()fdfd5B*ph5\5\5\5\zz 2EmrRh - :_eW[r 5:V*0KKKK44j.@KKKKj.KKKKj.KKKKj K(*fdfd55\5\5\5B*\ph"X " 2@:_6]"W " k`p5\ -Emr^~2G:V-044j;@ j; jDjD(-fdfd5B*ph5\5\5\5\(( vcitationL/L ye h 2 Char"5CJ$KHOJPJQJ\^JaJ$( Og0LS2V 2 Ys0Ǐvc >*B*ph<O"< &W h1stpagehead2CJaJv2v J( M_abstract)3dT*$1$8$9D]^B*CJKHPJaJphtHbBb 3n)M_Text4dT*$1$8$9D`B*CJKHPJaJphtHdRd `M_ISSN5$dT*$1$8$9Da$B*CJKHPJaJphtHtbt fM_Tablecaption6$dT*$1$8$9Da$B*CJKHPJaJphtHh/rh YDefault71$7$8$H$1B*CJOJQJ^J_HaJmH nHphsH tH2qr2 Y0CM128 B*PJph2qr2 !0CM119 B*PJphBeB &W HTML Or> &W haffiliationsgCJaJBB &WhcorrespondencehCJaJBB &W habstractheadi 5CJaJ6O6 &W habstractjCJaJ6O6 &W hkeywordskCJaJ@@ &WhabbreviationslCJaJ6O6 &W hfootnotemCJaJ0O0 &Whhead1nCJ aJ4O4 &Whhead2o@&CJaJ4O4 &Whhead3p@&CJaJ8O8 &W hparagraphqCJaJPO"P &WhparagraphindentrdWDd`dCJaJB2B &WhparagraphcontisCJaJVBV &Whemphasisshadingt-DM CJaJ<OR< &W hequationu$a$CJaJ@b@ &W hequationnov$a$CJaJRrR &Whunnumberedlistw^`CJaJNN &W hbulletedlistx^`CJaJLL &Whnumberedlist1y^`CJHOH &W htabletitle z$@& CJKHaJ<O< &W htablebody{CJaJ<O< &W htablehead|CJaJHOH &Whtablefootnote }^CJaJDD &W htablelegend ~^CJaJJJ &WhacknowledgmentheadCJaJBOB &WhacknowledgmentCJaJ>O> &W happendixheadCJ aJ>O"> &W happendixtextCJaJDO2D &Whreferencehead 5CJaJ8OB8 &W hreferenceCJaJFRF &Whcontinuedlist1 ^CJDObD &Whfigurecaption@&CJaJ:r: &W hfigureimage$a$RaR &Whfigurecaptioncontinued <@& `` &W hcomputercode h8p @ CJOJQJ00 &Whhead4@&CJDD &Whkeywordshead P&C5;:: &W hhead1 P&C 5;PJ@@ &W hhead2 P&C5PJnHtH>> &W habstract P&C5PJBB &W hkeywords P&C PJnHtHD D &Whreferencehead P&C;V  V &Whacknowledgmenthead P&C ;nHtHB" B &Whabstracthead P&C;F2 F &Whcorrespondence FPY6BqB B &Whaffiliations FPY6>R > &W hnotationheadnHtHBb B &W hnotationtext CJnHtH@!r @ &W htitle FMD5PJnHtH8 8 &W hhead1 FMD5CJ4 4 &W hhead2 FMDCJ8 8 &W hhead3 FMD6CJ8a 8 &W hauthors FMDCJFq F &Whaffiliations FMD6CJ@ @ &W habstract FMD$a$5D D &W hkeywords FMD$a$5CJ: : &W hfootnote FMDCJB B &Whparagraph FMD$a$CJN! N &Whparagraphindent FMD$a$CJ>" > &Whtabletitle FMDCJ<2 < &Whtablebody FMDCJ<B < &Whtablehead FMDCJDaR D &Whfigurecaption FMDCJFb F &Whacknowledgment FMDCJ8Ar 8 &Whreference FMDD D &Whabbreviations FMDCJ@1 @ &Whreferencehead FMDN N &Whacknowledgmenthead FMD5PK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭V-\".B-?7}>FTlon77Ԝx?|+NST2 XiEꭶ?j]m^_^+P[wD+PW-W_YW ͶW5 R ~,VAFXuVKsKTCV]rŦZ-t  ;b6#42% qv8›q. B˟TDFLڐAB&~ ^] ُ=q==~NV;(VG:=ՃxiJ!x?>?< }a\G5TLx?y;~nьHbwc:EGP~Ds |w<4rg!Rt|+c m߆6Il!Q] sZ;aQITjYV`<$6D='Ienb~k3MHýS^P\wr^+j~k~vt~t«(:zQk_۶sWb/?ѹS)uzݜnrʵ+Am~޽: 5ˁWrbJAүsUTjzf5η1T>汀*^PK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 0_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!.theme/theme/theme1.xmlPK-! ѐ' theme/theme/_rels/themeManager.xml.relsPK] + 0 **HK P7,=,  Ed{==,  $&*BDK!!T # @H 0(  0(  B S  ? OLE_LINK1 OLE_LINK2 OLE_LINK118 OLE_LINK119 OLE_LINK97 OLE_LINK98 OLE_LINK74 OLE_LINK73 OLE_LINK58 OLE_LINK59 OLE_LINK93 OLE_LINK94||vvi i ,  --vRRi i i i ,  y z ,  , ; *urn:schemas-microsoft-com:office:smarttagschsdate9*urn:schemas-microsoft-com:office:smarttagsplace8*urn:schemas-microsoft-com:office:smarttagsCity=*urn:schemas-microsoft-com:office:smarttags PlaceType=*urn:schemas-microsoft-com:office:smarttags PlaceName  12189930DayFalse IsLunarDate IsROCDateMonthYear Ybnw`zeiw ~ 3 ;  ) , | ) , 3333333)67=>DF=R $ ' ) , ,-55EESXclx'(+,6X``zz##9966==DD<<==PRr - O O f f ) ,  4>7(+7W_AV{v0wKt$"fZJ*Ril&F:1.AG@LRI 1}x2RYHdz^`zo(H\^H`\)\^`\.\^`\.4\^4`\) \^ `\.| \^| `\. \^ `\)\^`\. ^`B*o(ph()\^`\)T\^T`\.\^`\. \^ `\)@ \^@ `\. \^ `\.\^`\),\^,`\.^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(hh^h`CJOJQJo(88^8`CJOJQJo(o^`CJOJQJo(  ^ `CJOJQJo(  ^ `CJOJQJo(xx^x`CJOJQJo(HH^H`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo( \^`\hH. H\H^H`\hH) \^`\hH. \^`\hH. 4\4^4`\hH)  \ ^ `\hH. | \| ^| `\hH.  \ ^ `\hH) \^`\hH.h^h`o(.H\^H`\)\^`\.\^`\.4\^4`\) \^ `\.| \^| `\. \^ `\)\^`\.^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`CJOJQJo(^`CJOJQJo(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo( LR4>(+ZJ* 1}RY&Ff_AwKAG x(`        42                 z        u6z 8T V4J7]8|};Ki'G{GzpMkUV@LZz_ .o>\z_ wfom 3KM  }$B%i&Ogjv  Xg0^19u& ix^}Nun%05>k ;NwCEKlLSng]i. Y5 U ^[ 8z l   " ( of  + 9 D vD M gV o + / / > H 4J L dX Y 4s Tt   ' 7 8; @ E Z a x qNCUOZ4x|C"s2H[cVi&u=w{6AAEFU g-@NG\Wcm)1O`n6!)|18FQFQselmr[S!"5%'m))#1$<$#"$#$/$J$T$]$%6%=%e%6i%o%t% &&a&E&nT&Y&'r& '1'5'J'(r()(+(0(<(E(J(P_(Mp(R)b)3n)# *UE*yG*VM*k]*4^*~u*z*|*B*1o+ ,,#,,,_1,M,9\,^,F--z=-I-=N-Q-.V*.@5.qN.X.h.x.//;/HE/)`/0&00.00K0P0{Q01f1&(1/B1D1\1b1}12$2(2*2+q24w2x3%3)3W3Y3b]3l34Z44$494R455;5o5x5L6666 #6W.6C6UE6+K6K}6~67r:7G7G7(U7vv7|738l?8bO82\8*o8+9yL9n9w92y9:%:D,:G:T:;;!;K.;[;c;g;;<S<ak<4n<yn<Qt<t<Ay<P=\=B=wF=X=@{=>> >A>S$>D:>w>0y>?T?Y?@K@/A@pH@S@\@q@w@ ApAAAu>AKAsAB(B>BBBKBCC1C:COQCWCZC `CkC {CDH0DOD[DQ_D+bD~cDvDCyD'EuHAHYaH=lH)IBI,MI\I`I9jI!JmPJSQJ`JUmJ K9K>KSKVVK[KtKLL}PL(}LJMlM rMX N("N`1N3N5NSNSNaNbNkNzNO $O%OZ0O/6O3JOjONPMDPHPQ(Q21Q2Q67Qo7QxR>Eܻı./6Cd"Al9\F\S\W\i\j\ y\}\ ^#^F^/.^N^aa^n __I_T_L__N_-T__\_iq__!`"`B`C`Mj`o`&a\am a aM!a1a b%b(b4b FbWbYb}c-c8c:c acgclcd#dNdBcd4|d eqee.e1ey7eWeye-f+Hf:Jf g2gDFgJg%SgK^glgrg%=hRbhohi;Vixi jjjj9j=j_jcjrjzj kJkYXk#wk9ll lll,l.lOlwSl:Tl,mmDm{3m ;m,=m_nRNn`nqnVot%otFoKoXomoioppkOp[pD^pVqlq .q 2qEqIqcqoq>rY r rr!r;rFr[`rYss%s)sCs^[scs$tc't=t+ct|tunusu v vU v` vn vv,vYSvTvr^vWww7w;w`Zwx x#x'xv6x8x;xmFxcyxyySy"z+zOVz%XzBxz {N+{I{ey{5|f ||%:|XF|g|}y|z|{|3} }>&,9EҰs2<~K~Q~a~'w2?_s}49lZQFR|~i]"#57}Xtciq '#G- %CNWXIm A!Hh!#'%(/DV9Y _!'}GSL/VWs m*H3J=Zq[WoUXPg35KLVVZknri (C2Q6BPuQR_T  4_JQ`rxO !*5HgQldfp|MOZQsck[j<~s(4[$qHxp+02RmYm#G9:PWkBox{z'o(R.@8#C&!3KCX^ pp$**<U&k(@11a]dq7)Xo()GgB'\'_CC[i$kR;@w94JPp/x{hD EgFP4UF^g.JR"6; JWblj`swsA 9.s3:x?|Lx(~ =H1w379; )9_u~asc\dofWoz8j{sta8%46;rbt*x cq4;NV[uqA6YsG b%/KU@rC#q<JQ^nv!@ORf }" #/JoZK^rLwG a (3dCwj2SiU`zg612-6+*eQ|s2 (UeD"O S*I:eF JMkLnVx$fEwH(g1LW#{Yrw&UIP'TZfciq5v)4&|5?YK;k$ 2A7:x)`/j6LWZXzX~7HYn~AJ cd683<>XGt+=GSX|"h(EFMu#D6{CHLhH"-.4kK6\`;gy q@;EGSa3Adv-!ARq sNs` /A1<WOUU%kX!KEVcjt / H,l}R0=vWmoxa7MSx##+6;LVit}~(K0eD"LLM^`hv:0P $\36Z7F]nn//]kqr{ GYrpy $e' .m/k?#r-\wOx *f",I~;Xv/&>BcLQ)kuQSSbkn .IB Hntwv>vrX~huU/d8GUU~z 7C+E_fhJinn}!*8Wb'x8WFW_8lW3MoehYq!%AF{v4DGJ5_+2ouvh)|l|m d6\)`#i?K --;HAMW_d9"}"++0'4DD6MUF)KnY-47=L2efm r8q{WWemfixn  7Zq+N[k]b-/Rc9:EK[&<DSJpSUJafks~B##0:|m:|1-7XK] L5,,J&W6_,/OCg@~? 'Ndv~'094;KCpG5[fis(( *,WewxGW"X_DloClntzz6}; # AbbrJrnNameAccepted ArticleIDAutoRedact State CheckHeader CopyrightCpyYrDOIEN.InstantFormat EN.Layout EN.Librariesex_AddedHTMLPreformatex_eXtylesBuildEX_LAST_PALETTE_TABex_WordVersioneXtylesExtylesTagDescriptors iceFileDir iceFileNameiceJABR iceJournaliceJournalName icePublishericeType,NE.Ref{8078658D-63C9-4FC5-9CA3-5DCE3B63E541},NE.Ref{8295618E-39D1-4C78-BB29-74A7E7CDFCB7},NE.Ref{D30EC35E-E599-4B92-BAAA-500A7DD1F117},NE.Ref{F6BD787A-FF54-4BBA-BF38-A6C676ED90FF} ne_docsoft ne_docversion ne_stylenamePreEdit Baseline PathPreEdit Baseline TimestampPreEdit Up-Front LossReceivedFront. Chem. Sci. Eng. MM-DD-YYYY1111readyF.(c) Higher Education Press and Springer-Verlag2015DOI 10.1007/s?????-???-????-?<ENInstantFormat><Enabled>1</Enabled><ScanUnformatted>1</ScanUnformatted><ScanChanges>1</ScanChanges><Suspended>0</Suspended></ENInstantFormat><ENLayout><Style>FCSE</Style><LeftDelim>{</LeftDelim><RightDelim>}</RightDelim><FontName>Times New Roman</FontName><FontSize>10</FontSize><ReflistTitle></ReflistTitle><StartingRefnum>1</StartingRefnum><FirstLineIndent>0</FirstLineIndent><HangingIndent>720</HangingIndent><LineSpacing>0</LineSpacing><SpaceAfter>0</SpaceAfter><HyperlinksEnabled>1</HyperlinksEnabled><HyperlinksVisible>0</HyperlinksVisible></ENLayout><Libraries><item db-id="p590rtasqfdraper95dvpf9op52apeep9e2x">LY<record-ids><item>1</item><item>3</item><item>4</item><item>5</item><item>7</item><item>9</item><item>10</item><item>11</item><item>12</item><item>13</item><item>14</item><item>15</item><item>16</item><item>17</item><item>18</item><item>20</item><item>21</item><item>23</item><item>24</item><item>25</item><item>26</item><item>28</item><item>30</item><item>32</item><item>33</item><item>36</item><item>38</item><item>44</item><item>46</item><item>47</item><item>48</item><item>49</item><item>51</item><item>53</item><item>55</item><item>56</item><item>57</item><item>58</item><item>59</item><item>60</item><item>63</item><item>64</item><item>65</item></record-ids></item></Libraries> Courier New3068411.0activeBook Reference|bok|Conference Reference|conf|Edited Book Reference|edb|Electronic Reference|eref|Journal Reference|jrn|Legal Reference|lgl|Other Reference|other|Thesis Reference|ths|Unknown Reference|unknown|C:\Users\Administrator\Desktop FCSE-template for manuscript.docFCE1FCE:Frontiers of Chemical Science and Engineering-Frontiers of Chemical Science and EngineeringHEPResearch Article ADDIN NE.Ref.{8078658D-63C9-4FC5-9CA3-5DCE3B63E541}<Citation><Group><References><Item><ID>8</ID><UID>{30DA3AEE-4D51-430F-9089-2E4ECD41AC04}</UID><Title>Prediction of protein solubility in</Title><Template>Journal Article</Template><Star>0</Star><Tag>0</Tag><Author>Diaz, Armando A; Tomba, Emanuele; Lennarson, Reese; Richard, Rex; Bagajewicz, Miguel J; Harrison, Roger G</Author><Year>2010</Year><Details><_doi>10.1002/bit.22537</_doi><_created>60368984</_created><_modified>60368984</_modified><_url>http://doi.wiley.com/10.1002/bit.22537</_url><_journal>Biotechnology and Bioengineering</_journal><_volume>105</_volume><_issue>2</_issue><_pages>374-383</_pages><_tertiary_title>Biotechnol. Bioeng.</_tertiary_title><_date>57899520</_date><_isbn>00063592</_isbn><_accessed>60368984</_accessed><_db_updated>CrossRef</_db_updated></Details><Extra><DBUID>{16B7F896-03AA-4747-8972-AA0FE0E665F0}</DBUID></Extra></Item></References></Group></Citation> I ADDIN NE.Ref.{8295618E-39D1-4C78-BB29-74A7E7CDFCB7}<Citation><Group><References><Item><ID>60</ID><UID>{D28545E8-308B-4D0D-9E50-AC72AB6F4E40}</UID><Title>Misbehaving Proteins</Title><Template>Book</Template><Star>0</Star><Tag>0</Tag><Author>Murphy, Regina M; Tsai, Amos M</Author><Year>2006</Year><Details><_author_aff>Department of Chemical and Biological Engineering, University of Wisconsin, 15 Engineering Drive, 53706-1691, Madison, Wisconsin, USA ; Human Genome Sciences, 14200 Shady Grove Road, 20850, Rockville, Maryland, USA</_author_aff><_db_provider>SpringerLink</_db_provider><_doi>10.1007/978-0-387-36063-8</_doi><_isbn>978-0-387-30508-0</_isbn><_publisher>Springer New York</_publisher><_subject>Proteomics;Biochemistry, general;Biochemical Engineering;Biotechnology;Analytical Chemistry</_subject><_url>http://link.springer.com/book/10.1007/978-0-387-36063-8</_url><_created>60369718</_created><_modified>60369719</_modified><_db_updated>SpringerLink</_db_updated></Details><Extra><DBUID>{16B7F896-03AA-4747-8972-AA0FE0E665F0}</DBUID></Extra></Item></References></Group></Citation>  ADDIN NE.Ref.{D30EC35E-E599-4B92-BAAA-500A7DD1F117}<Citation><Group><References><Item><ID>62</ID><UID>{677C843F-5649-4F19-AB7C-39E182551402}</UID><Title>Predicting the Solubility of Recombinant Proteins in Escherichia coli</Title><Template>Journal Article</Template><Star>0</Star><Tag>0</Tag><Author>Wilkinson, David L; Harrison, Roger G</Author><Year>1991</Year><Details><_created>60387343</_created><_date>1991-05-01</_date><_date_display>1991/05//print</_date_display><_issue>5</_issue><_modified>60387343</_modified><_ori_publication>Nature Publishing Company</_ori_publication><_pages>443-448</_pages><_url>http://dx.doi.org/10.1038/nbt0591-443</_url><_volume>9</_volume></Details><Extra><DBUID>{16B7F896-03AA-4747-8972-AA0FE0E665F0}</DBUID></Extra></Item></References></Group></Citation>  ADDIN NE.Ref.{F6BD787A-FF54-4BBA-BF38-A6C676ED90FF}<Citation><Group><References><Item><ID>8</ID><UID>{30DA3AEE-4D51-430F-9089-2E4ECD41AC04}</UID><Title>Prediction of protein solubility in</Title><Template>Journal Article</Template><Star>0</Star><Tag>0</Tag><Author>Diaz, Armando A; Tomba, Emanuele; Lennarson, Reese; Richard, Rex; Bagajewicz, Miguel J; Harrison, Roger G</Author><Year>2010</Year><Details><_doi>10.1002/bit.22537</_doi><_created>60368984</_created><_modified>60368984</_modified><_url>http://doi.wiley.com/10.1002/bit.22537</_url><_journal>Biotechnology and Bioengineering</_journal><_volume>105</_volume><_issue>2</_issue><_pages>374-383</_pages><_tertiary_title>Biotechnol. Bioeng.</_tertiary_title><_date>57899520</_date><_isbn>00063592</_isbn><_accessed>60368984</_accessed><_db_updated>CrossRef</_db_updated></Details><Extra><DBUID>{16B7F896-03AA-4747-8972-AA0FE0E665F0}</DBUID></Extra></Item></References></Group></Citation> MSWordNoteExpress 2.0 )Y%m'Yf[ZSXf[MOeDC:\Users\Administrator\Desktop\FCSE-template for manuscript$base.doc2015/6/10 17:05:32complete MM-DD-YYYY@-( + @X@Unknown G*Ax Times New Roman5Symbol3. *Cx Arial;Wingdings;([SOSimSunWDeckfN[{SOArial Unicode MS?= *Cx Courier NewG=  jMS Mincho-3 fg;= |8ўSOSimHeiA$BCambria Math 1hET6gaXGؓ3g@  ?!%),.:;>?]}    & 0 2 3 : !6"000 0 0 0000006:>@DZ\^ =@\]^$([{  0 0 000000Y[];[i2  ?qHX  $P22! xx Front administratordell , >N i Z'`IZ'8         Oh+'0  < H T `lt|FrontadministratorNE.RepNormaldell64Microsoft Office Word@@ˀLa@\@ ՜.+,D՜.+, X`lt| LY  x0X`hpx_ax_px_t   !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]_`abcdefghijklmnopqrstuvwxyz{|}~Root Entry FC9Data ^1Table^WordDocumentF0SummaryInformation(DocumentSummaryInformation8CompObjn  FMicrosoft Word 97-2003 ĵ MSWordDocWord.Document.89q