Synopsis
Conformational Design plays a key role in the medicinal chemistry of small molecule drug candidates. The emergence of generative AI models to assist molecular design and free-energy-perturbation techniques critically depend on accurate prediction of 3D ligand conformations. Here we bring together cutting-edge computational methods with experimental free ligand NMR solution conformations and protein-ligand X-ray and CryoEM structures to craft the medicines of tomorrow. We will discuss ligand rigidification and physicochemical optimisation strategies for protein-protein interaction inhibitors, PROTACs, molecular glues, antibody-drug-conjugate payloads and other new modalities. This RSC-BMCS event aims at building a community that shares conformational design strategies, technologies, and successful case studies. It will complement other rational drug design events and promote more successful research into future medicines.
Who should attend?
This symposium will provide great learnings for medicinal chemists, computational chemists, structural biologists, biophysicists and NMR analytical chemists with an academic or industry interest in drug discovery. Prior knowledge in conformational design will not be required.
Registration Fees:
RSC Member 鈥� 拢115.00
Non-Member 鈥� 拢165.00
RSC Student Member 鈥� 拢40.00
Student Non-Member 鈥� 拢60.00
Bursaries
The RSC-BMCS are offering a small number of bursaries to attend the meeting. Applications are open to PhD and post-doctoral applicants studying at academic institutions or non-profit institutions. Preference will be given to members of the RSC-BMCS. Bursary applications are also invited from RSC members who are of working age, but currently unemployed and from those who may have difficulty in funding their attendance. The bursary application deadline is Friday 17th January 2025. Please download the application form on the right hand side. Please send all completed application forms to events@hg3.co.uk
Exhibitor and sponsorship opportunities
Exhibition Package includes (拢900):
鈥� Two stand personnel with access to the scientific talks
鈥� A table and 2 chairs
鈥� Your logo and A4 promotional page in the pdf of the delegate handbook
鈥� Your logo in the rolling slides, shown during the breaks
Organising Committee
Markus Schade, AstraZeneca (Chair)
Chris Swain, Cambridge MedChem Consulting (Treasurer)
Luca Carlino, AstraZenceca
Conformational Design plays a key role in the medicinal chemistry of small molecule drug candidates. The emergence of generative AI models to assist molecular design and free-energy-perturbation techniques critically depend on accurate prediction of 3D ligand conformations. Here we bring together cutting-edge computational methods with experimental free ligand NMR solution conformations and protein-ligand X-ray and CryoEM structures to craft the medicines of tomorrow. We will discuss ligand rigidification and physicochemical optimisation strategies for protein-protein interaction inhibitors, PROTACs, molecular glues, antibody-drug-conjugate payloads and other new modalities. This RSC-BMCS event aims at building a community that shares conformational design strategies, technologies, and successful case studies. It will complement other rational drug design events and promote more successful research into future medicines.
Who should attend?
This symposium will provide great learnings for medicinal chemists, computational chemists, structural biologists, biophysicists and NMR analytical chemists with an academic or industry interest in drug discovery. Prior knowledge in conformational design will not be required.
Registration Fees:
RSC Member 鈥� 拢115.00
Non-Member 鈥� 拢165.00
RSC Student Member 鈥� 拢40.00
Student Non-Member 鈥� 拢60.00
Bursaries
The RSC-BMCS are offering a small number of bursaries to attend the meeting. Applications are open to PhD and post-doctoral applicants studying at academic institutions or non-profit institutions. Preference will be given to members of the RSC-BMCS. Bursary applications are also invited from RSC members who are of working age, but currently unemployed and from those who may have difficulty in funding their attendance. The bursary application deadline is Friday 17th January 2025. Please download the application form on the right hand side. Please send all completed application forms to events@hg3.co.uk
Exhibitor and sponsorship opportunities
Exhibition Package includes (拢900):
鈥� Two stand personnel with access to the scientific talks
鈥� A table and 2 chairs
鈥� Your logo and A4 promotional page in the pdf of the delegate handbook
鈥� Your logo in the rolling slides, shown during the breaks
Organising Committee
Markus Schade, AstraZeneca (Chair)
Chris Swain, Cambridge MedChem Consulting (Treasurer)
Luca Carlino, AstraZenceca
